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THE
BEHAVIORAL TERATOGENIC EFFECT OF CIMETIDINE ON THE OFFSPRINGS OF ALBINO RATS
ABSTRACT
During childhood, the capacity of sexual
response and the experience of sexual pleasure as well as the potential for
orgasm exists at least in a proportion of children whether this apparently
variable potential among childrenreflects different learning experiences during
childhood, different opportunities for realizing the potential or different
gentile influences is not known. The importance of gonadal hormones in
particular testosterone, in organizing early brain development and function has
been discussed earlier. During childhood, gonadal steroid hormones are title in
evidence, but from the ages of 9 or 10 years they start to increase as the
child approaches puberty from there on we have to consider the activating role
of those hormones on sexuality and the impact they have on sexuality, and the
impact they have on sexuality, and the impact they have on sexuality during
three stages of the life course around puberty and during early adolescence
during adulthood until muddle age, and during the later years.
An adult male’s continued interest in sex
depends on he’s having a normal level of circulating testosterone. If an
otherwise normal male has his testosterone lowered by testicular suppressive
drugs, he experiences a decline in sexual interest, which returns when the
process is reversed. In case of testicular impairment (primary or secondary
hypogonadison). When testosterone level fall below normal range almost all
males experience a decline in sexual interest and capacity for ejaculation.
This is reversed by testosterone replacement the raphy. This is a robust,
predictable finding across a substantial number of placebo-controlled studies.
A similar pattern is observed with spontaneous erection during sleep, or
nocturnal penile tumescence, which decline and return with testosterone
withdrawal and replacement these erections are interesting manifestations of
the sexually arousability of the brain uncomplicated by cognitive processes,
and this evidence clearly points to the role of testosterone in central sexual
arousal mechanism it is important to emphasis, however, that normal levels of
testosterone are necessary but not sufficient for normal levels of sexual
desire. These are the factors which can inhibit or alter sexual desire in the
presence of normal testosterone levels.
The role of testosterone the become less
clear as men get older there is a normal, but variable, tendency for tester one
levels of decline on men beyond the fifth decade, and this is often accompanied
by an age-related decline in sexual interest. This is sometimes referred to
inappropriately as the “male menopause” However, there is no clear evidence
that that this pattern can be reversed by testosterone replacement. It is
possible that there is a decline in responsiveness to testosterone in addition
to a fall in the hormone level (Schiavs, 1999).
There is also a common (though variable)
age-related decline in erectile responsiveness, such that are men get older
erections develop less consistently and are less strong and less
well-sustained. The mechanisms for this are not well understood but may be
related to change in neuro transmitter responsiveness in erectile tissues
(Cerner and Chirst, 2000).
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